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Identifying the origins of wintertime climate variations in the Northern Hemisphere requires careful attribution of the role of El Niño–Southern Oscillation (ENSO). For example, Aleutian low variability arises from internal atmospheric dynamics and is remotely forced mainly via ENSO. How ENSO modifies the local sea surface temperature (SST) and North American precipitation responses to Aleutian low variability remains unclear, as teasing out the ENSO signal is difficult. This study utilizes carefully designed coupled model experiments to address this issue. In the absence of ENSO, a deeper Aleutian low drives a positive Pacific decadal oscillation (PDO)-like SST response. However, unlike the observed PDO pattern, a coherent zonal band of turbulent heat flux–driven warm SST anomalies develops throughout the subtropical North Pacific. Furthermore, non-ENSO Aleutian low variability is associated with a large-scale atmospheric circulation pattern confined over the North Pacific and North America and dry precipitation anomalies across the southeastern United States. When ENSO is included in the forcing of Aleutian low variability in the experiments, the ENSO teleconnection modulates the turbulent heat fluxes and damps the subtropical SST anomalies induced by non-ENSO Aleutian low variability. Inclusion of ENSO forcing results in wet precipitation anomalies across the southeastern United States, unlike when the Aleutian low is driven by non-ENSO sources. Hence, we find that the ENSO teleconnection acts to destructively interfere with the subtropical North Pacific SST and southeastern United States precipitation signals associated with non-ENSO Aleutian low variability.